Dammarane sapogenin PPD induces apoptosis of non-small cell lung cancer cells

Featured Articles


082

Recent advances in ginseng as cancer therapeutics: a functional and mechanistic overview

18 0 The first issue of Natural Product Reports in 2015 will publish a comprehensive review regarding ginseng’s anti-cancer effects and underlying mechanisms. Here we summarize this review as follows:...

Protopanaxadiol

Pharmacological Review of Ginsenoside Dammarane Saponin Rh2

3 0 Please download here. Related PostsAntiallergic activity of ginsenoside Rh2 Rb1 prevents osteoporosis by inhibiting osteoclastogenesis PPD induces apoptosis of glioma cells Rh2 improves insulin sensitivity Antiestrogenic effect of...

081

Pharmacological Review of Ginsenoside Dammarane Saponin Rg1

0 0 Please download here. Related PostsRb1 prevents inflammation and apoptosis in human articular chondrocytes Anti-arthritic effect of ginsenoside Rb1 PPT improves hematopoiesis in myelosuppression mice Rh2 induces β-cell regeneration...

042

Pharmacological Review of Ginsenoside Dammarane Saponin Rb1

0 0 Please download here. Related PostsGinsenoside Rb1 attenuates activated microglia-induced brain damage Ginsenoside Rb1 prevents neuronal injury and stimulates growth of axons and dendrites Protective effects of ginsenoside Rb1...

029

Pharmacological Review of Aglycon Dammarane Sapogenin (AGS) – Protopanaxatriol (PPT)

0 0 Please download here. Related PostsGinsenoside Rb1 improves postoperative fatigue syndrome Ginsenoside rb1 protects the heart from hypoxia/ischemia Ginsenosides Rg1 and Rb1 are the major ingredients of Fufang Danseng...

006

Pharmacological Review of Aglycon Dammarane Sapogenin (AGS) – Protopanaxadiol (PPD)

0 0 Please download here.   Related PostsDripping pill can be an effective drug delivery method for oral dammarane sapogenins Ginsenosides Rg1 activates neural stem cells Immunomodulation by ginsenoside Rg1...

008

Antiallergic activity of ginsenoside Rh2

0 0 The antiallergic activities of ginsenosides, which were isolated from acid-treated ginseng (Panax ginseng, Araliaceae), and their metabolites by human intestinal bacteria were measured. Ginsenoside Rh2, which is a...

107

Rb1 prevents osteoporosis by inhibiting osteoclastogenesis

0 0 Ginsenosides, the main active components of ginseng, have been reported possessing anti-osteoporosis activity in ovariectomized rats. However, the active ingredient and the mechanisms underlying the anti-osteoporosis activity of...

028

PPD induces apoptosis of glioma cells

0 0 20S-Protopanaxadiol (PPD) is an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponins. In the present study, PPD was used to induce cytotoxicity for two human glioma cell lines,...

132

Rh2 improves insulin sensitivity

0 0 Ginsenoside Rh2, one of the ginsenosides contained in the Panax ginseng root, was employed to screen the effect on insulin resistance of rats induced by a diet containing...

Down
pause
Up

 

18
0



Non-small-cell lung carcinoma (NSCLC) is any type of epithelial lung cancer other than small cell lung carcinoma (SCLC). The American Cancer Society’s estimates for lung cancer in the United States for 2014 are:

  • About 224,210 new cases of lung cancer (116,000 in men and 108,210 in women)
  • An estimated 159,260 deaths from lung cancer (86,930 in men and 72,330 among women).

Lung cancer accounts for about 27% of all cancer deaths and is by far the leading cause of cancer death among both men and women. Each year, more people die of lung cancer than of colon, breast, and prostate cancers combined.

Although chemotherapy is being used both pre-operatively (neoadjuvant chemotherapy) and post-operatively (adjuvant chemotherapy), NSCLCs are relatively insensitive to chemotherapy, compared to small cell carcinoma. Therefore, to find new chemo regimens and conquer its resistance is increasingly becoming the focus of current NSCLC research.

20(s)-protopanaxadiol (PPD) can be isolated from American ginseng (Panax quinquefolium L.), and sevral studies have demonstrated its strong anti-cancer activity on a number of cancer cells. In this study, Dr. Zhang applied PPT to non-small cell lung cancer, and found PPT also quickly triggered cancer cell death.

The study used fluorescence stainning, gel electrophoresis, and flow cytometry to investigate the PPD influence on NSCLC cells. Several other complicated technologies were also employed to explore the underlining mechanisms. With PPD treatment, NSCLC cells underwent noticeable apoptosis dose- and time-dependently. Some anti-apoptosis genes like Bcl-1/bax were inhibited, and pro-apoptosis chemicals (e.g., cytochrome C, AFI, Smac, etc.) leaked from mitochondria to trigger cascade reactions of caspase activation (caspases are enzymes stimulating apoptosis).

Besides, PPD shut down the signaling pathways of cancer cell survival. A kinase named AKT, which stimulates cell growth and division, was significantly inhibited.  AKT inhibitor could synergistically enhanced PPD’s pro-apoptotic effect on NSCLC cells.

In summary, through inhibition of PI3K/AKT signaling pathway, PPD induces NSCLC cell apoptosis, implying PPD’s therapeutical potential in NSCLC treatment.

Above results are extracted from Dr. Rui Zhang’s doctoral dissertation “20(s)-protopanaxadiol induces apoptosis of NSCLC A549 cells by inhibition of P13K/AKT signaling pathway” (2009, Jilin University, China).

Dammarane sapogenin PPD induces apoptosis of non-small cell lung cancer cells
1 vote, 5.00 avg. rating (93% score)

读者同时也阅读了...


Hit Counter provided by laptop reviews