敗血症是一種致命的血液感染，又稱為系統性炎症反應綜合徵。敗血症甚至可以在感染消失後仍持續存在。嚴重的敗血症甚至可以引起器官功能衰竭，導致死亡。
在這片雜誌發表的文章顯示：在大鼠的動物研究中，人參達瑪烷皂苷Rb1能夠幫助機體抵抗感染，顯著降低敗血症的並發症和死亡率。 這個結果意味著，人體在感染時使用達瑪烷皂苷Rb1可能幫助機體抵抗感染，具有重要的臨床價值。
Related Articles:
Protective effects of ginsenoside rb1 on septic rats and its mechanism.
Biomed Environ Sci. 2014 Apr;27(4):300-3
Authors: Wu LL, Jia BH, Sun J, Chen JX, Liu ZY, Liu Y
Abstract
This study aims to observe the protective effects of ginsenoside Rb1 on liver and lung in rats with septic shock and reveal its mechanism.
Rats were randomly divided into three groups: sham, cecal ligation and puncture (CLP), and CLP with ginsenoside Rb1.
Then, the survival rate, arterial blood pressure, TLR4 mRNA, and TNF-α levels were determined.
The liver and lung tissues were stained with hematoxylin-eosin (HE).
The overall survival rate of the Rb1 group was significantly higher than that of the CLP group. Mean arterial blood pressure went down in both the CLP and Rb1 groups after CLP, and there was a significant difference both in the sham and Rb1 groups when compared with the CLP group.
The Rb1 treatment group had markedly lower TLR4 mRNA expression and TNF-α levels than the CLP group. In the CLP group, pathology showed swelling, degeneration, necrosis, and neutrophil infiltration in the liver and alveolar epithelial cells. However, in the Rb1 group, there was mild degeneration and slight neutrophil infiltration, but no obvious necrosis.
Rb1 may improve the survival rate, ameliorate arterial blood pressure, and protect the liver and lung in septic shock rats by downregulating the expression of TLR4 mRNA and inhibiting the production of TNF-α.
PMID: 24758759 [PubMed – in process]
Source: Dammarane Saponins
