Brief review of Asian ginseng pharmacology

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Recent advances in ginseng as cancer therapeutics: a functional and mechanistic overview

6 0 The first issue of Natural Product Reports in 2015 will publish a comprehensive review regarding ginseng’s anti-cancer effects and underlying mechanisms. Here we summarize this review as follows:...

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Pharmacological Review of Ginsenoside Dammarane Saponin Rb1

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Antiallergic activity of ginsenoside Rh2

0 0 The antiallergic activities of ginsenosides, which were isolated from acid-treated ginseng (Panax ginseng, Araliaceae), and their metabolites by human intestinal bacteria were measured. Ginsenoside Rh2, which is a...

107

Rb1 prevents osteoporosis by inhibiting osteoclastogenesis

0 0 Ginsenosides, the main active components of ginseng, have been reported possessing anti-osteoporosis activity in ovariectomized rats. However, the active ingredient and the mechanisms underlying the anti-osteoporosis activity of...

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PPD induces apoptosis of glioma cells

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Rh2 improves insulin sensitivity

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Central nervous system

  • Asian ginseng (ginseng in brief) can regulate the excitatory and inhibitory processes in the central nervous system, but the excitatory activity takes prodominance.
  • Ginseng in apropriate doses can improve the learning and memory ability.
  • Ginseng also reduces fatigue after exercise, partially due to its stimulation on lipid mobilization, protein and RNA synthesis.
  • Ginseng has intrinsic cholinomimetic and catacholamine-mimetic activity, and can enhance functions of choline system.
  • Ginseng promotes synthesis of proteins, RNA and DNA.
  • Ginseng protects the brain from ischemia and reperfusion injury.

Improve the adaptability of the body

  • As a adaptogen, ginseng changes the responsiveness of the body towards various harmful stimuli and stresses.

Cardiovascular system

  • Cardiac function: low-dose ginseng stimulates cardiac muscle to increase cardiac output and rate, however, high-dose ginseng suppresses the heart contraction and rate instead.
  • Myocardial protection:  ginseng improves the resistance of cardiac muscle towards ischemia, and reduces injuries due to ischemia and reperfusion.
  • Vasoactive activity: ginseng can dilate blood vessels, though its vasorestrictive action was documented; therefore, both reduction and increase of blood pressure are reported.
  • Increase resistance to anoxia: ginseng increases the survival time of animals under anoxia environment.
  • Hematopoiesis: ginseng stimulates bone marrow to produce blood cells.
  • Blood thinning effect: ginseng inhibits platelet aggregation.
  • Lipid-lowering and anti-atherosclerosis: ginseng reduces blood levels of cholesterol, triglycerides, and LDL, but increases HDL.

Anti-Shock

  • Ginseng not only alleviates symptoms of anaphylactic shock, but also improve hypovolumic shock secondary to fluid or blood loss.

Effect on the Liver

  • Ginseng increases the activity of transforming enzymes in the liver and therefore enhances the detoxification capability of the liver.

Endocrine system

  • Ginseng stimulates pituitary-adrenal system and then incrases the level of corcoticosteroids
  • Ginseng can stimulate sexual glands in both male and female. Ginseng increases testosterone level.

Hypoglycemic action

  • Ginseng restores insulin receptor sensitivity and reduces blood glucose level.

Brief review of Asian ginseng pharmacology
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