手术后疲劳（postoperative fatigue,pof）是一组表现为乏力、失眠、疼痛、抑郁、紧张、焦虑等证候群，是机体应激（在这里特指手术后创伤）后个体在生活适应过程中，关于环境要求与自我平衡的一个转归过程。在这个转归过程中，机体的应激状态（在这里特指手术后疲劳综合征）程度过重或持续时间过长时，往往会引起人体某些器官或系统功能紊乱，导致疾病的发生。
在一项由74例老年胃肠外科病人参与的研究中，病人随机分为人参皂甙组和对照组,人参皂甙组采用手术前人参皂甙胶囊口服,对照组不作特殊处理。观察手术后疲劳指数、首次下床时间、手术前后血白细胞总数、中性分类、血白蛋白、血糖、以及转铁蛋白、C-反应蛋白等指标。结果显示：人参皂甙组的手术后疲劳指数,手术后1周-手术前的血白细胞计数之差、手术后3日-手术前的白蛋白、血糖之差,手术后-周血清C-反应蛋白增高与对照组相比均有明显差异。（摘自《第九届全国中西医结合普通外科学术交流大会暨胆道胰腺疾病新进展学习班论文汇编》2005年）
最近的研究进一步的研究表明，人参皂苷中的Rb1可能是发挥抗疲劳作用的主要承载者。
Related Articles:
Ginsenoside Rb1 improves postoperative fatigue syndrome by reducing skeletal muscle oxidative stress through activation of the PI3K/Akt/Nrf2 pathway in aged rats.
Eur J Pharmacol. 2014 Jun 26;
Authors: Zhuang CL, Mao XY, Liu S, Chen WZ, Huang DD, Zhang CJ, Chen BC, Shen X, Yu Z
Abstract
Ginsenoside Rb1 is reported to possess anti-fatigue activity, but the mechanisms remain unknown.
The aim of this study was to investigate the molecular mechanisms responsible for the anti-fatigue effect of ginsenoside Rb1 on postoperative fatigue syndrome induced by major small intestinal resection (MSIR) in aged rat.
Aged rats with MSIR were administrated with ginsenoside Rb1 (15mg/kg) once a day from 3 days before surgery to the day of sacrifice, or with saline as corresponding controls. Rats without MSIR but going through the same surgery procedure were administrated with saline as blank controls.
Anti-fatigue effect was assessed by open field test; superoxide dismutase, reactive oxygen species and malondialdehyde in skeletal muscle were determined. The mRNA levels of Akt2 and Nrf2 in skeletal muscle were measured by real-time quantitative PCR. The activation of Akt and Nrf2 were examined by western blot and immunohistofluorescence.
Our results revealed that ginsenoside Rb1 significantly increased the journey and the rearing frequency, decreased the time of rest in aged rats with MSIR. In addition, ginsenoside Rb1 significantly reduced reactive oxygen species and malondialdehyde release and increased the superoxide dismutase activity of skeletal muscle in aged rats with MSIR.
Ginsenoside Rb1 also increased the expression of Akt2 and Nrf2 mRNA, up-regulated Akt phosphorylation and Nrf2 nuclear translocation.
These findings indicate that ginsenoside Rb1 has an anti-fatigue effect on postoperative fatigue syndrome in aged rat, and the mechanism possibly involves activation of the PI3K/Akt pathway with subsequent Nrf2 nuclear translocation and induction of antioxidant enzymes.
PMID: 24975098 [PubMed – as supplied by publisher]
Source: Dammarane Saponins
